• Information on Ibogaine

    Ibogaine Journal provides up to date information on the emerging clinical applications for ibogaine in heroin addiction treatment.
  • Ibogaine Treatment

    We are a source for news, emerging treatments, research and general information on the alkaloid compound, ibogaine.

Recent Articles

Ibogaine Treatment

Treating Serious Addiction with Ibogaine HCL

Ibogaine Treatment

A wealth of information and research suggests that ibogaine treatment may be twice as effective as current, standard addiction treatment modalities. This brief article examines a patient legally treated with ibogaine HCL at a facility in Costa Rica and follows him for three months after receiving ibogaine treatment.


Possible mechanisms of action of ibogaine and its potential utility in the management of addictions: A review

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Despite efforts to treat drug addiction, the health, social and economic costs associated with substance abuse and dependence remain intolerable high. One treatment strategy is to use pharmacological methods, such as aversion therapy, replacement therapy, vaccines and anti-craving medication, to combat addiction. Unfortunately, there are numerous problems with these therapies and many treatment programs remain unsuccessful. Therefore, there remains great interest in finding a pharmacological agent that could prove beneficial as a therapeutic intervention for addiction. Thus, this paper presents a discussion of the anti-addiction medication ibogaine. The review begins with an overview of the history of ibogaine, including research on its potential mechanisms of action. Studies investigating ibogaine’s ability to reduce the rewarding properties of a variety of addictive drugs are also evaluated. The presented findings provide preliminary evidence for ibogaine’s ability to interrupt the physiological and psychological aspects of addiction, and it’s effectiveness in treating drug abuse and withdrawal is considered.
Methodology for the literature search: The methods used to search for the information contained within this review included three database search engines: Dalhousie University libraries, McGill University libraries and PubMed. Keywords and phrases searched for were “ibogaine”, “ibogaine and addiction”, “iboagine and withdrawal”, and “iboagine pharmacology”. The search was conducted between January, 2013 and October, 2013. Articles selected for discussion in this review included those involving animal or human studies, experimental designs, and an ibogaine intervention. Results were not taken into consideration for inclusion as the examination of commonalities and contradictions between articles will be discussed.

Keywords: Addiction, Ibogaine, Pharmacology, Withdrawal

Bwiti Tribe’s Ibogaine Use in Religious Rituals Spans 3000 Yrs

Protected Iboga Root Bark Consumed for Specific Group Ceremonies and by Hunters


Fifty years have past since college student/heroin addict, Howard Lotsoff tried ibogaine. After an introspective, three day hallucination, Lotsoff found that he no longer craved heroin and had skipped the withdrawal pains. He would champion this approach in the West for the rest of his life. Other heroin addicts report remarkably similar experiences after Ibogaine therapy.

Chemical Properties of Ibogaine Molecule

Ibogaine's Molecular Structure

NMDA Receptor Action

Unlike typical serotonergic psychedelic compounds, ibogaine acts as a selective antagonist for both the NMDA receptor and the k oipiod receptor set, offering a possible means to explain why the alkaloid compound is said to reduce or eliminate symptoms of opiate withdrawal.